2016 Anime Villains Tournament - Round 3, Match 8
Dio Brando - Jojo's Bizzare Adventure
Reiko Tamura - Parasyte
No question here; my vote goes to Dio Brando.
random vote Reiko
You thought this would be a close match, but…..!
A shame, I put some effort into finding a good pic of Reiko too. :P