It probably won't have too much impact on a NA release.
There have been other examples in the past: either volumes were cancelled in favor of releasing a single BD-Box, or the home video release was canned outright. In both cases, it's usually due to unexpectedly low sales, like under a few hundred units or double-digit sales.
Unfortunately, I can't think or find a good concrete example off the top of my head. It's unusual, but not unheard of.