I like Eden of the East, it's a great series. But Spice and Wolf holds a lot of significance for me. Watching that series way back in 2008 probably turned me into the fan I am today. Before Spice and Wolf, I had no idea that anime could be so intelligent and still be compelling. It was honestly kind of a big turning point for me, personally. I started watching new genres of anime that I never would have even looked twice at. And it all started with a cute wolf-girl talking about economics.